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CAS No. 50-04-4 | Cortisone acetate

Name: Cortisone acetate CAS No. 50-04-4 MF:C23H30O6 MW:402.48 Purity:97% Package: 5g,25g,200g,500g,1kg Worldwide Delivery

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Biochemicals

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Product introduction

Introduction and application of CAS No. 50-04-4 | Cortisone acetate

Synonyms:11,20-trione,17,21-dihydroxy-pregn-4-ene-21-acetate;

11-dehydro-17-hydroxycorticosterone-21-acetate;

17,21-dihydroxypregn-4-ene-3,11,20-trioneacetate;

4-PREGNEN-17ALPHA,21-DIOL-3,11,20-TRIONEACETATE;

4-PREGNEN-17,21-DIOL-3,11,20-TRIONE21-ACETATE;

17ALPHA,21-DIHYDROXY-4-PREGNENE-3,11,20-TRIONE21-ACETATE

Specification:

ITEMS	SPECIFICATION
CAS	50-04-4
MF	C23H30O6
MW	402.48
Melting point	237-240 °C
Boiling point	577.3±50.0 °C
Density	1.26±0.1 g/cm3
Acidity coefficient	12.32±0.60
Color	White to off-white
Solubility	Almost insoluble in water, easily soluble in dichloromethane, soluble in dioxane, slightly soluble in acetone, slightly soluble in ethanol (96%) and methanol.
Form	crystalline powder
Storage condition	2-8°C

Chemical Properties:

White needle-like crystals or crystalline powder (acetone), odorless. Stable in air. Mp239-241℃, specific optical rotation [α]20D+164° (0.5%, acetone), [α]23D+169° (chloroform), [α]25D+208°-+217° (dioxane) , the ethanol solution of this product has maximum absorption at the wavelength of 240nm. Easily soluble in chloroform (1:4), soluble in acetone (1:75), slightly soluble in ethanol and ether, and insoluble in water. This product dissolves in sulfuric acid and is yellow without fluorescence (different from hydrocortisone acetate).

use;

Biochemical research, adrenocortical hormone drugs, have anti-inflammatory, anti-allergic and other effects.

Intermediate of prednisone acetate. It is an anti-inflammatory agent in itself.

Treat adrenocortical hypofunction, rheumatoid arthritis, rheumatism, lupus erythematosus and other diseases.

For the treatment of adrenocortical hypofunction, rheumatoid arthritis, rheumatism, lupus erythematosus and other diseases

production method:

Using progesterone acetate as raw material, 11-keto-16, 17α epoxy progesterone is obtained through hydrogen oxide oxidation, Wohlmann's oxidation, black rhizome biological oxidation, and chromic anhydride oxidation in sequence, and the ring is opened by hydrobromic acid. , hydrodebromination to obtain cortisone, which reacts with iodine, reacts with molten potassium acetate to obtain crude product, and finally recrystallizes.

Package and transportation :

Package: 5g,25g,200g,500g,1kg